Title : Deoxidized gulose moiety attenuates the pulmonary toxicity of 6'-deoxy-bleomycin Z without effect on its antitumor activity.

Pub. Date : 2021 Apr

PMID : 33450497






1 Functional Relationships(s)
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1 Our investigations suggested the biological activities of BLM or its analogues are mainly depended on the C-terminal amine, while the changed C-terminal amine endowed BLM Z with much higher pulmonary toxicity comparing to BLM-sulfate, whereas the deoxidized gulose unit with same C-terminal amine evidently attenuated the pulmonary toxicity of 6"-DO-BLM Z without effect on antitumor activity. gulose BLM RecQ like helicase Homo sapiens