Pub. Date : 2021 May
PMID : 33450459
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BLG) cross-linked with epsilon poly l-lysine (BCEP and BCP), and found to possess high loading capacity, high aqueous solubility and site-specific oral delivery of a poorly soluble nutraceutical (curcumin), improving its physicochemical properties and biological activity in-vitro and ex-vivo. | Curcumin | beta-lactoglobulin | Bos taurus |
| 2 | By forming nanocomplexes of curcumin with BLG and succ. | Curcumin | beta-lactoglobulin | Bos taurus |
| 3 | BLG, the aqueous solubility of curcumin was markedly increased by ~160-fold and ~86-fold, respectively. | Curcumin | beta-lactoglobulin | Bos taurus |
| 4 | BLG prevent release of encapsulated curcumin when subjected to gastric fluids as it is resistant to breakdown on exposure to pepsin at acidic pH. | Curcumin | beta-lactoglobulin | Bos taurus |
| 5 | BLG with E-PLL significantly enhanced curcumin"s permeability in an in-vitro Caco-2 cell monolayer model compared to curcumin solution (dissolved in 1% DMSO), or non-crosslinked BLG/succ. | Curcumin | beta-lactoglobulin | Bos taurus |
| 6 | In a mouse-derived intestinal epithelial 3D organoid culture stimulated with IL-1beta, BLG-CUR and crosslinked BCEP nanoparticles reduced the production of inflammatory cytokines and chemokines such as Tnfalpha and Cxcl10 more than curcumin solution or suspension while these nanoparticles were non-toxic to organoids. | Curcumin | beta-lactoglobulin | Bos taurus |