Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity.

Pub. Date : 2021 Mar 1

PMID : 33450278






1 Functional Relationships(s)
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1 2-AG activation of both CB1 and CB2 receptors and the PI3K/Akt downstream signaling pathway, as substantiated by the use of Akt2-/-mice, afforded neuroprotection against AMPA excitotoxicity. glyceryl 2-arachidonate cannabinoid receptor 2 Rattus norvegicus