Title : Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity.

Pub. Date : 2021 Apr

PMID : 33446525






1 Functional Relationships(s)
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1 Significance Statement This is the first study to clarify that AADAC is responsible for the activation of eslicarbazepine acetate, an antiepileptic prodrug, to eslicarbazepine, an active form, in the human liver and intestines. eslicarbazepine arylacetamide deacetylase Homo sapiens