Pub. Date : 2021 May 4
PMID : 33444083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We observed that participants on 3000 mg/day dose of metformin had significantly lower levels of TNF-alpha (p < .001) and IFN-gamma (p = .014) compared to those on other dosages (1000 mg and 2000 mg/day). | Metformin | tumor necrosis factor | Homo sapiens |
2 | After adjusting for age, gender, dose and duration of metformin use, we observed that participants who took higher doses of metformin had significantly reduced levels of TNF-alpha (beta = -0.0297, 95% CI = (-0.005 to -0.002) p < .001. | Metformin | tumor necrosis factor | Homo sapiens |
3 | After adjusting for age, gender, dose and duration of metformin use, we observed that participants who took higher doses of metformin had significantly reduced levels of TNF-alpha (beta = -0.0297, 95% CI = (-0.005 to -0.002) p < .001. | Metformin | tumor necrosis factor | Homo sapiens |
4 | Metformin dosage independently predicted reduced TNF-alpha levels with 14.4% variations in the metformin dosage levels. | Metformin | tumor necrosis factor | Homo sapiens |
5 | Increased metformin dosage suppresses TNF-alpha levels in systemic circulation and hence might contribute to its beneficial effects. | Metformin | tumor necrosis factor | Homo sapiens |