Title : Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects.

Pub. Date : 2021 May 4

PMID : 33444083






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1 We observed that participants on 3000 mg/day dose of metformin had significantly lower levels of TNF-alpha (p < .001) and IFN-gamma (p = .014) compared to those on other dosages (1000 mg and 2000 mg/day). Metformin tumor necrosis factor Homo sapiens
2 After adjusting for age, gender, dose and duration of metformin use, we observed that participants who took higher doses of metformin had significantly reduced levels of TNF-alpha (beta = -0.0297, 95% CI = (-0.005 to -0.002) p < .001. Metformin tumor necrosis factor Homo sapiens
3 After adjusting for age, gender, dose and duration of metformin use, we observed that participants who took higher doses of metformin had significantly reduced levels of TNF-alpha (beta = -0.0297, 95% CI = (-0.005 to -0.002) p < .001. Metformin tumor necrosis factor Homo sapiens
4 Metformin dosage independently predicted reduced TNF-alpha levels with 14.4% variations in the metformin dosage levels. Metformin tumor necrosis factor Homo sapiens
5 Increased metformin dosage suppresses TNF-alpha levels in systemic circulation and hence might contribute to its beneficial effects. Metformin tumor necrosis factor Homo sapiens