Title : Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death.

Pub. Date : 2020 Dec 22

PMID : 33443209






1 Functional Relationships(s)
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1 In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner. Chlorogenic Acid thymoma viral proto-oncogene 1 Mus musculus