Title : Exploring the beneficial role of ROCK inhibitors in sepsis-induced cerebral and cognitive injury in rats.

Pub. Date : 2021 Oct

PMID : 33440039






1 Functional Relationships(s)
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1 Administration of nonselective ROCK inhibitor, fasudil (10 and 30 mg/kg), and selective ROCK1 inhibitor, Y27632 (10 and 30 mg/kg), attenuated the sepsis-induced increase in the S100beta and NSE, IL-1beta, TNF-alpha, BCL-2, Caspases-3, ROCK1 and ROCK2 in septic rats and significantly memory and learning. Y 27632 enolase 2 Rattus norvegicus