Title : Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.

Pub. Date : 2021 Feb 22

PMID : 33434183






3 Functional Relationships(s)
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1 In the perfused mouse small intestine the selective SSTR5 antagonist (SSTR5a) stimulated glucose-induced GLP-1 secretion to a larger degree than the SSTR2 antagonist (SSTR2a). Glucose glucagon Mus musculus
2 In parallel, mice lacking the SSTR5R showed increased glucose-induced GLP-1 secretion. Glucose glucagon Mus musculus
3 In summary, we demonstrate that selective SSTR antagonists can improve glucose control primarily through the intestinal GLP-1 system in mice. Glucose glucagon Mus musculus