Title : LncRNA SOX2-OT regulates AKT/ERK and SOX2/GLI-1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases.

Pub. Date : 2021 Apr

PMID : 33433063






2 Functional Relationships(s)
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1 We detected that the SOX2-OT/SOX2/GLI-1 axis promotes resistance to tyrosine kinase inhibitor (TKI)-erlotinib and cisplatin-based therapy. Cisplatin SOX2 overlapping transcript Homo sapiens
2 In addition, we identified that inhibition of SOX2-OT and reduced expression of SOX2/GLI-1 sensitizes lung cancer cells to EGFR/TKI-erlotinib or cisplatin-based treatment. Cisplatin SOX2 overlapping transcript Homo sapiens