Title : Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.

Pub. Date : 2021 Mar 1

PMID : 33427061






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lysophosphatidic acid (LPA) increases PDGFB and CTGF production and secretion by proximal tubule (PT) cells through LPA2-receptor-Galphaq-alphavbeta6-integrin mediated activation of TGFB1. lysophosphatidic acid transforming growth factor beta 1 Homo sapiens
2 Lysophosphatidic acid (LPA) increases PDGFB and CTGF production and secretion by proximal tubule (PT) cells through LPA2-receptor-Galphaq-alphavbeta6-integrin mediated activation of TGFB1. lysophosphatidic acid transforming growth factor beta 1 Homo sapiens