Title : Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions.

Pub. Date : 2021

PMID : 33425684






1 Functional Relationships(s)
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1 Molecular modeling revealed that the SARS-CoV-2 Spike glycoprotein might bind to nicotinic acetylcholine receptors (nAChRs) through a cryptic epitope homologous to snake toxins, substrates well documented and known for their affinity to the nAChRs. Acetylcholine surface glycoprotein Severe acute respiratory syndrome coronavirus 2