Title : Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer.

Pub. Date : 2021 Feb

PMID : 33420377






1 Functional Relationships(s)
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1 Mechanistically, we found that PFK158 downregulated the CBPt/Cis-induced upregulation of RAD51 expression and enhanced CBPt/Cis-induced DNA damage as demonstrated by an increase in gamma-H2AX levels in HEC-1B and ARK-2 cells, potentially revealing a means to enhance PFK158-induced chemosensitivity. PFK-158 RAD51 recombinase Homo sapiens