Title : PCSK9 Hapten Multicopy Displayed onto Carrier Protein Nanoparticle: An Antiatherosclerosis Vaccine.

Pub. Date : 2019 Sep 9

PMID : 33417782






4 Functional Relationships(s)
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1 Then, sequences of PCSK9 were conjugated onto the surface of nanoparticles by "click" chemistry to consequently form an orderly structured of nanovaccine with repetitive hapten display. nanovaccine proprotein convertase subtilisin/kexin type 9 Homo sapiens
2 Compared with conventional PCSK9 peptide vaccine, our immunization study demonstrated that the PCSK9 multicopy display nanovaccine (PMCDN) was able to induce higher titers of PCSK9 antibody and more efficient lymph node drainage and improve endocytosis by antigen presenting cells. nanovaccine proprotein convertase subtilisin/kexin type 9 Homo sapiens
3 Compared with conventional PCSK9 peptide vaccine, our immunization study demonstrated that the PCSK9 multicopy display nanovaccine (PMCDN) was able to induce higher titers of PCSK9 antibody and more efficient lymph node drainage and improve endocytosis by antigen presenting cells. nanovaccine proprotein convertase subtilisin/kexin type 9 Homo sapiens
4 Compared with conventional PCSK9 peptide vaccine, our immunization study demonstrated that the PCSK9 multicopy display nanovaccine (PMCDN) was able to induce higher titers of PCSK9 antibody and more efficient lymph node drainage and improve endocytosis by antigen presenting cells. nanovaccine proprotein convertase subtilisin/kexin type 9 Homo sapiens