Pub. Date : 2021 May
PMID : 33417223
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Based on the premise that cocaine induces both reactive oxygen species (ROS) as well as microglial activation, we hypothesized that cocaine-mediated microglial activation involves both ROS and NLRP3 signaling pathways. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Based on the premise that cocaine induces both reactive oxygen species (ROS) as well as microglial activation, we hypothesized that cocaine-mediated microglial activation involves both ROS and NLRP3 signaling pathways. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | We found that microglia exposed to cocaine exhibited significant induction of NLRP3 and mature IL-1beta expression. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Intriguingly, blockade of ROS (Tempol) attenuated cocaine-mediated priming of NLRP3 and microglial activation (CD11b). | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Blockade of NLRP3 by both pharmacological (MCC950) as well as gene silencing (siNLRP3) approaches underpinned the critical role of NLRP3 in cocaine-mediated activation of inflammasome and microglial activation. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Blockade of NLRP3 by both pharmacological (MCC950) as well as gene silencing (siNLRP3) approaches underpinned the critical role of NLRP3 in cocaine-mediated activation of inflammasome and microglial activation. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | Furthermore, cortical brain tissues of chronic cocaine-dependent humans also exhibited upregulated expression of the NLRP3 pathway mediators compared with non-cocaine dependent controls. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 9 | Furthermore, cortical brain tissues of chronic cocaine-dependent humans also exhibited upregulated expression of the NLRP3 pathway mediators compared with non-cocaine dependent controls. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 10 | Collectively, these findings suggest that cocaine activates microglia involving the NLRP3 inflammasome pathway, thereby contributing to neuroinflammation. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |
| 11 | NLRP3 can thus be considered as a potential therapeutic target for alleviating cocaine-mediated neuroinflammation. | Cocaine | NLR family pyrin domain containing 3 | Homo sapiens |