Title : Brucella-Induced Downregulation of lncRNA Gm28309 Triggers Macrophages Inflammatory Response Through the miR-3068-5p/NF-κB Pathway.

Pub. Date : 2020

PMID : 33414782






2 Functional Relationships(s)
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1 Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1beta and IL-18 secretion. gm28309 NLR family pyrin domain containing 3 Homo sapiens
2 Conclusions: Our study demonstrates, for the first time, that LncRNAs are involved in regulating immune responses during Brucella infection, and Gm28309, an lncRNA, plays a crucial role in activating NF-kappaB/NLRP3 inflammasome signaling pathway. gm28309 NLR family pyrin domain containing 3 Homo sapiens