Title : Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms.

Pub. Date : 2021 Jan 6

PMID : 33414419






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release. reactive oxygen NLR family pyrin domain containing 3 Homo sapiens
2 Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release. reactive oxygen NLR family pyrin domain containing 3 Homo sapiens