Pub. Date : 2021 Oct
PMID : 33411349
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | CD44 enhances adriamycin resistance in chronic myelogenous leukaemia cells K562. | Doxorubicin | CD44 molecule (Indian blood group) | Homo sapiens | ||
| 2 | INTRODUCTION: To investigate CD44 effects on the adriamycin-resistant in chronic myelogenous leukaemia cells K562, we explored the role of CD44 in the K562 cells migration and apoptosis. | Doxorubicin | CD44 molecule (Indian blood group) | Homo sapiens | ||
| 3 | We constructed K562/CD44 cells by transfection of an EGFP-SV40-CD44 plasmid, and adriamycin-resistant ability was confirmed by detecting migration and apoptosis-related proteins and mRNA expression using Western blotting and Real-time PCR respectively. | Doxorubicin | CD44 molecule (Indian blood group) | Homo sapiens | ||
| 4 | CONCLUSIONS: CD44 might be involved in adriamycin resistance via regulation of P-gp, MMP-2, MMP-9, and Bcl-2/Bax. | Doxorubicin | CD44 molecule (Indian blood group) | Homo sapiens | ||