Title : Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53.

Pub. Date : 2021 Feb 4

PMID : 33400924






1 Functional Relationships(s)
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1 Specifically, high-glucose-stimulated reactive oxygen species (ROS) signals AKT to phosphorylate AMPKalpha at S485/491, which facilitates the recruitment of MG53 and the subsequent ubiquitination and degradation of AMPKalpha. Glucose AKT serine/threonine kinase 1 Homo sapiens