Title : Effect of Azithromycin on Proinflammatory Cytokine Production in Gingival Fibroblasts and the Remodeling of Periodontal Tissue.

Pub. Date : 2020 Dec 30

PMID : 33396644






2 Functional Relationships(s)
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Protein Name
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1 In response to LPS stimulation, the gene expression levels of IL-6 and IL-8 in hGFs increased due to AZM in a concentration-dependent manner, and phosphorylation of nuclear factor kappa B (NF-kappaB) was also promoted. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
2 Thus, AZM may increase the expression of IL-6 and IL-8 under LPS stimulation to modify the inflammatory response and increase the expression of MMP-1 to promote connective tissue remodeling. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens