Pub. Date : 2020 Dec 23
PMID : 33389946
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combined Effects of Protocatechuic Acid and 5-Fluorouracil on p53 Gene Expression and Apoptosis in Gastric Adenocarcinoma Cells. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 2 | Moreover, the combined 5-FU/PCA exposure led to upregulation of p53 and downregulation of Bcl-2 protein when compared to the untreated control cells. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 3 | The mechanisms by which the combined 5-FU/PCA exposure exerts its effects are associated with upregulation of p53 gene expression and downregulation of Bcl-2 level. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 4 | Therefore, the combination of 5-FU with PCA not only could be a promising approach to potentially reduce the dose requirements of 5-FU but also could promote apoptosis via p53 and Bcl-2 signaling pathways. | Fluorouracil | tumor protein p53 | Homo sapiens |