Title : Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer.

Pub. Date : 2021 Feb 1

PMID : 33388655






3 Functional Relationships(s)
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1 Here, two series of novel thiohydantoin derivatives of enzalutamide as potent androgen receptor (AR) antagonists were designed and synthesized. enzalutamide androgen receptor Homo sapiens
2 Here, two series of novel thiohydantoin derivatives of enzalutamide as potent androgen receptor (AR) antagonists were designed and synthesized. enzalutamide androgen receptor Homo sapiens
3 Among them, compound 31c was identified as an AR antagonist which is 2.3-fold more potent than enzalutamide. enzalutamide androgen receptor Homo sapiens