Title : Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations.

Pub. Date : 2021 Mar

PMID : 33375991






3 Functional Relationships(s)
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1 Multivariate logistic regression was used to analyze the effects of TP53 mutation type on platinum resistance. Platinum tumor protein p53 Homo sapiens
2 TP53 mutations were associated with platinum sensitivity, even after adjusting for BRCA mutation status (OR 0.41, p = 0.048). Platinum tumor protein p53 Homo sapiens
3 After adjusting for BRCA mutations, TP53 mutations are associated with platinum sensitivity, and this effect is not dependent on TP53 mutation type. Platinum tumor protein p53 Homo sapiens