Pub. Date : 2020 Dec 24
PMID : 33374288
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells. | S-Adenosylmethionine | tumor protein p53 | Homo sapiens |
| 2 | PURPOSE: In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53. | S-Adenosylmethionine | tumor protein p53 | Homo sapiens |
| 3 | RESULTS: In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. | S-Adenosylmethionine | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSIONS: Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes. | S-Adenosylmethionine | tumor protein p53 | Homo sapiens |