Title : Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy.

Pub. Date : 2021 Jan

PMID : 33365058






1 Functional Relationships(s)
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1 Metformin increased the number of autophagosomes, green fluorescent LC3 puncta and the levels of LC3II/I, beclin 1, alpha-SMA and phosphorylated (p)-AMPK in the VSMCs that were treated with beta-glycerophosphate when compared to controls; whereas, calcium deposition and the expression levels of RUNX2 and p-mTOR were found to be decreased. Metformin actin alpha 1, skeletal muscle Homo sapiens