Title : Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis.

Pub. Date : 2021 Feb

PMID : 33359561






3 Functional Relationships(s)
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1 In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing. Oxysterols proprotein convertase subtilisin/kexin type 6 Homo sapiens
2 In U937 promonocytic cells and in human umbilical vein endothelial cells, an oxysterol mixture and HNE were able to up-regulate the level and activity of PCSK6, resulting in MMP-9 activation as demonstrated by PCSK6 silencing. Oxysterols proprotein convertase subtilisin/kexin type 6 Homo sapiens
3 For the first time, we demonstrated that both oxysterols and HNE, which substantially accumulate in the atherosclerotic plaque, up-regulate the activity of PCSK6. Oxysterols proprotein convertase subtilisin/kexin type 6 Homo sapiens