Title : Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation.

Pub. Date : 2020 Dec 24

PMID : 33357230






1 Functional Relationships(s)
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1 Inhibition of this cancer-cell-intrinsic AChE via pyridostigmine and physostigmine, or administration of acetylcholine (ACh), diminished PCa cell viability and invasion in vitro and in vivo via suppression of pERK signaling, and reduced tumor-associated macrophage (TAM) infiltration and serum pro-inflammatory cytokine levels. Physostigmine acetylcholinesterase (Cartwright blood group) Homo sapiens