Title : p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum-Derived Cells Stimulated by Tumor Necrosis Factor-α.

Pub. Date : 2021 Dec

PMID : 33355843






2 Functional Relationships(s)
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1 Results: TNF-alpha induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. SB 203580 tumor necrosis factor Homo sapiens
2 On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-alpha from HFCs. SB 203580 tumor necrosis factor Homo sapiens