Title : Persistently Elevated mTOR Complex 1-S6 Kinase 1 Disrupts DARPP-32-Dependent D1 Dopamine Receptor Signaling and Behaviors.

Pub. Date : 2021 Jun 1

PMID : 33353667






1 Functional Relationships(s)
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1 BACKGROUND: The serine-threonine kinase mTORC1 (mammalian target of rapamycin complex 1) is essential for normal cell function but is aberrantly activated in the brain in both genetic-developmental and sporadic diseases and is associated with a spectrum of neuropsychiatric symptoms. Serine CREB regulated transcription coactivator 1 Mus musculus