Title : Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34.

Pub. Date : 2020 Dec 18

PMID : 33352965






1 Functional Relationships(s)
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1 In cholangiocytes exposed to mitochondrial oxidative stress melatonin decreased the expression of proapoptotic stimuli (PTEN, Bax, miR-34), which was accompanied by the inhibition of a pivotal mediator of inflammatory response Nf-kappaB-p65 and the activation of antiapoptotic signaling (miR-132, Bcl2). Melatonin BCL2 associated X, apoptosis regulator Homo sapiens