Pub. Date : 2021 Jan 21
PMID : 33340488
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | We discovered that breast-cancer-derived lung metastases, but not the corresponding primary breast tumors, use the serine biosynthesis pathway to support mTORC1 growth signaling. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Mechanistically, pyruvate uptake through Mct2 supported mTORC1 signaling by fueling serine biosynthesis-derived alpha-ketoglutarate production in breast-cancer-derived lung metastases. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Consequently, expression of the serine biosynthesis enzyme PHGDH was required for sensitivity to the mTORC1 inhibitor rapamycin in breast-cancer-derived lung tumors, but not in primary breast tumors. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |