Title : STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening.

Pub. Date : 2021 Feb 21

PMID : 33337450






2 Functional Relationships(s)
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1 The application of the STAT3 inhibitor CP690,550 reduced the production of the IL-6 family and the formation of osteoclasts both in vitro and in vivo. tofacitinib signal transducer and activator of transcription 3 Homo sapiens
2 Inhibition of STAT3 by tofacitinib may be a potential treatment for aseptic loosening. tofacitinib signal transducer and activator of transcription 3 Homo sapiens