Title : Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2.

Pub. Date : 2020

PMID : 33329667






2 Functional Relationships(s)
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Protein Name
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1 In vitro analysis with 10 available compounds showed that CAG, ECG, GCG, EGCG, and PB2 inhibited the Mpro activity with an IC50 value, 2.98 +- 0.21, 5.21 +- 0.5, 6.38 +- 0.5, 7.51 +- 0.21, and 75.3 +- 1.29 muM, respectively, while CA, EC, EGC, GC, and PA2 did not have inhibitory activities. gallocatechol NEWENTRY Severe acute respiratory syndrome-related coronavirus
2 In vitro analysis with 10 available compounds showed that CAG, ECG, GCG, EGCG, and PB2 inhibited the Mpro activity with an IC50 value, 2.98 +- 0.21, 5.21 +- 0.5, 6.38 +- 0.5, 7.51 +- 0.21, and 75.3 +- 1.29 muM, respectively, while CA, EC, EGC, GC, and PA2 did not have inhibitory activities. gallocatechol NEWENTRY Severe acute respiratory syndrome-related coronavirus