Pub. Date : 2021 Mar
PMID : 33326114
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/Nrf2/Prx2/ASK1/P38 after traumatic brain injury in mice. | astaxanthine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Mechanically, ATX treatment dramatically enhanced the expression of peroxiredoxin 2 (Prx2), nuclear factor-erythroid 2-related factor 2 (Nrf2), and sirtuin 1 (SIRT1), while it downregulated the phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and p38. | astaxanthine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Mechanically, ATX treatment dramatically enhanced the expression of peroxiredoxin 2 (Prx2), nuclear factor-erythroid 2-related factor 2 (Nrf2), and sirtuin 1 (SIRT1), while it downregulated the phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and p38. | astaxanthine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Additionally, Nrf2 knockout abated the neuroprotective effects of ATX in TBI. | astaxanthine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 5 | CONCLUSION AND IMPLICATIONS: ATX improved the neurologic functions and protected the brain from injury after TBI, primarily by reducing oxidative stress and neuronal death via SIRT1/Nrf2/Prx2/ASK1/p38 signaling pathway. | astaxanthine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |