Title : Hormonal modulation of ESR1 mutant metastasis.

Pub. Date : 2021 Feb

PMID : 33323970






1 Functional Relationships(s)
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1 Androgen receptor (AR) protein levels were increased in mutant models, and the AR agonist dihydrotestosterone significantly inhibited estrogen-regulated gene expression, EMT, and distant metastasis in vivo, suggesting that AR may play a role in distant metastatic progression of ESR1 mutant tumors. Dihydrotestosterone estrogen receptor 1 Homo sapiens