Pub. Date : 2020
PMID : 33312948
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study aimed to investigate the effects of vismodegib and itraconazole on the expression of Hedgehog (HH) genes (PTCH1, SMO, and GLI1), cell cycle and cell death in OSCC cells. | Itraconazole | smoothened, frizzled class receptor | Homo sapiens |
| 2 | Gene expression of PTCH1, SMO, and GLI1 decreased in response to 24 h of treatment with vismodegib or itraconazole. | Itraconazole | smoothened, frizzled class receptor | Homo sapiens |
| 3 | An increase in the DNA fragmentation was observed after treatment and both inhibitors induced apoptosis after 72 h. In conclusion, SMO inhibitors vismodegib and itraconazole demonstrably reduced the expression of HH genes in CAL27 OSCC cell line. | Itraconazole | smoothened, frizzled class receptor | Homo sapiens |