Title : Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1.

Pub. Date : 2020 Dec 10

PMID : 33303821






1 Functional Relationships(s)
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1 Using IKK, mTORC1 and ceramide production inhibitors, we were able to blunt IRS1 serine 307 phosphorylation and restore insulin stimulation of Akt. Serine CREB regulated transcription coactivator 1 Mus musculus