Title : Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway.

Pub. Date : 2021 Jan

PMID : 33302036






4 Functional Relationships(s)
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1 Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway. peoniflorin nucleotide-binding oligomerization domain containing 2 Mus musculus
2 This work aims to demonstrate that Gram-positive bacteria may be an underlying cause of experimental colitis in mice through the muramyl dipeptide (MDP)-nucleotide-binding oligomerization domain-containing protein-2 (NOD2) pathway and paeoniflorin inhibits the pathway above to alleviate experimental colitis. peoniflorin nucleotide-binding oligomerization domain containing 2 Mus musculus
3 Paeoniflorin also inhibited mRNA and protein expression of MDP-NOD2 pathway components and decreased the levels of related inflammatory cytokines. peoniflorin nucleotide-binding oligomerization domain containing 2 Mus musculus
4 Overall, the results indicated that Gram-positive bacteria promote the occurrence of colitis via up-regulation of MDP-NOD2 pathway, and paeoniflorin is able to decrease the infiltration of Gram-positive bacteria in intestine and inhibit Gram-positive bacteria-dependent MDP-NOD2 pathway to alleviate mice colitis. peoniflorin nucleotide-binding oligomerization domain containing 2 Mus musculus