Title : Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism.

Pub. Date : 2021 Jan 7

PMID : 33300910






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Neuraminidase 3 (NEU3) is a key enzyme catalyzing the conversion of ganglioside GM3 to ceramide trihexosides (Gb3), whose expression is increased in drug-resistant HCT-116/L cells. Gangliosides neuraminidase 3 Homo sapiens
2 Neuraminidase 3 (NEU3) is a key enzyme catalyzing the conversion of ganglioside GM3 to ceramide trihexosides (Gb3), whose expression is increased in drug-resistant HCT-116/L cells. Gangliosides neuraminidase 3 Homo sapiens
3 These findings reveal that BPIS increases the chemo-sensitivity by remodeling NEU3-mediated ganglioside GM3 catabolism, and it may be applied as a novel drug for facilitating the effectiveness of chemotherapeutic agents in CRC. Gangliosides neuraminidase 3 Homo sapiens