CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
2	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
3	We show that heparin/HS binds to Spike directly, and facilitates the attachment of Spike-bearing viral particles to the cell surface to promote viral entry.	Heparitin Sulfate	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2
4	We show that heparin/HS binds to Spike directly, and facilitates the attachment of Spike-bearing viral particles to the cell surface to promote viral entry.	Heparitin Sulfate	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2