Pub. Date : 2021 Mar 1
PMID : 33296710
7 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | European Journal of Pharmaceutical Sciences: PHASCI-D-20-01517R2Inhibitory effects of vandetanib on creatinine transport via renal organic cation transporter OCT2. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 2 | We examined the interaction of vandetanib with the human organic cation transporter 2 (hOCT2) stably expressed in human embryonic kidney (HEK) 293 cells. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 3 | We examined the interaction of vandetanib with the human organic cation transporter 2 (hOCT2) stably expressed in human embryonic kidney (HEK) 293 cells. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 4 | Vandetanib inhibited the uptake of creatinine mediated by hOCT2 in a dose-dependent manner. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 5 | The IC50 value for vandetanib inhibition of creatinine uptake by hOCT2 was 3.7 +- 1.0 muM (average +- SE of three separate experiments). | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 6 | Vandetanib showed markedly higher affinity for hOCT2 than cimetidine and trimethoprim. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||
| 7 | These results suggest that hOCT2 may play a crucial role in elevating the serum creatinine levels, as well as increasing the risk of renal impairment during vandetanib administration. | vandetanib | solute carrier family 22 member 2 | Homo sapiens | ||