Pub. Date : 2021 Jan 11
PMID : 33290564
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway. | 8-ohdg | apurinic/apyrimidinic endodeoxyribonuclease 1 | Homo sapiens |
| 2 | 8-Oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway. | 8-ohdg | apurinic/apyrimidinic endodeoxyribonuclease 1 | Homo sapiens |
| 3 | In this work, we studied coordinated BER of 8-oxodGuo by hOGG1 and APE1 in nucleosome core particles and found that histones transiently formed DNA-protein cross-links (DPCs) with active repair intermediates such as 3"-phospho-alpha,beta-unsaturated aldehyde (PUA) and 5"-deoxyribosephosphate (dRP). | 8-ohdg | apurinic/apyrimidinic endodeoxyribonuclease 1 | Homo sapiens |