Pub. Date : 2020 Dec 3
PMID : 33289703
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 2 | Atorvastatin could decrease the expression of alpha-synuclein Ser129 and NADPH oxidase 2 (NOX2), increase the protein expression of LC3II/I, and promote autophagy flow. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 3 | Atorvastatin could decrease the expression of alpha-synuclein Ser129 and NADPH oxidase 2 (NOX2), increase the protein expression of LC3II/I, and promote autophagy flow. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 4 | To further confirm that atorvastatin protection was achieved by inhibiting NOX2, we injected at midbrain with NOX2 shRNA (M) lentivirus and found that silent NOX2 produced the same effect as atorvastatin. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 5 | To further confirm that atorvastatin protection was achieved by inhibiting NOX2, we injected at midbrain with NOX2 shRNA (M) lentivirus and found that silent NOX2 produced the same effect as atorvastatin. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 6 | To further confirm that atorvastatin protection was achieved by inhibiting NOX2, we injected at midbrain with NOX2 shRNA (M) lentivirus and found that silent NOX2 produced the same effect as atorvastatin. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 7 | Further research found that atorvastatin could reduce MPTP-induced oxidative stress damage, while inhibiting NOX2 decreased the antioxidative stress effect of atorvastatin. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 8 | Our results suggest that atorvastatin can improve muscle capacity, anxiety and depression by inhibiting NOX2, which may be related to NOX2-mediated oxidative stress and autophagy. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |
| 9 | Our results suggest that atorvastatin can improve muscle capacity, anxiety and depression by inhibiting NOX2, which may be related to NOX2-mediated oxidative stress and autophagy. | Atorvastatin | cytochrome b-245, beta polypeptide | Mus musculus |