Title : Leukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology.

Pub. Date : 2021 Jul

PMID : 33285161






1 Functional Relationships(s)
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1 The administration of LTD4 to Ptges-/- mice, which display enhanced LTC4 synthesis similar to aspirin exacerbated respiratory disease (AERD), completely blocked the physiologic response to subsequent lysine-aspirin inhalation challenges, as well as increases in IL-33, type 2 cytokines, and biochemical markers of mast cell and platelet activation. Aspirin prostaglandin E synthase Mus musculus