Title : Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT-1: Influence on 18 F-FDG PET Uptake.

Pub. Date : 2021 May

PMID : 33278334






3 Functional Relationships(s)
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1 Tyrosine kinase inhibitors reduce glucose uptake by binding to an exofacial site on hGLUT-1: Effects on 18 F-FDG PET uptake. Fluorodeoxyglucose F18 solute carrier family 2 member 1 Homo sapiens
2 We evaluated the interaction of several classes of TKIs with human glucose transporter-1 (hGLUT-1) in FaDu and GIST-1 cells by measuring [3 H]2-deoxy-D-glucose ([3 H]2-DG) and [3 H]FDG uptake. Fluorodeoxyglucose F18 solute carrier family 2 member 1 Homo sapiens
3 hGLUT-1 inhibition by TKIs may have implications for routine [18 F]FDG-PET monitoring of tumor response in patients. Fluorodeoxyglucose F18 solute carrier family 2 member 1 Homo sapiens