Title : XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.

Pub. Date : 2020 Dec 4

PMID : 33277471






1 Functional Relationships(s)
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1 These findings reveal that genetic disruption of the hepatic 12-hour clock links to the onset and progression of NAFLD development via transcriptional regulator XBP1, and demonstrate a role for XBP1 and the 12-hour clock in the modulation of phospholipid composition and the maintenance of lipid homeostasis. Phospholipids X-box binding protein 1 Homo sapiens