Pub. Date : 2020 Nov 30
PMID : 33265983
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. | Corticosterone | brain derived neurotrophic factor | Mus musculus |
| 2 | Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway in CORT-induced depression. | Corticosterone | brain derived neurotrophic factor | Mus musculus |
| 3 | We found that CORT injection promoted depression-like behavior and significantly decreased BDNF and TrkB expression in the hippocampus. | Corticosterone | brain derived neurotrophic factor | Mus musculus |
| 4 | Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression. | Corticosterone | brain derived neurotrophic factor | Mus musculus |