Pub. Date : 2020 Nov 25
PMID : 33255632
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma. | Temozolomide | ligand of numb-protein X 1 | Homo sapiens | ||
| 2 | The ligand of numb protein 1 (LNX1), a known regulator of Notch signaling by targeting negative regulator Numb, is strongly upregulated after TMZ therapy (p < 0.0001) and is negatively correlated with survival of GBM patients. | Temozolomide | ligand of numb-protein X 1 | Homo sapiens | ||
| 3 | LNX1 is also upregulated after TMZ therapy in multiple PDX lines with concomitant downregulations in Numb and upregulations in intracellular Notch1 (NICD). | Temozolomide | ligand of numb-protein X 1 | Homo sapiens | ||