Title : The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans.

Pub. Date : 2020 Dec

PMID : 33254717






4 Functional Relationships(s)
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1 In animals, we found that arsenic exposures caused difficulties of social interaction and increased stereotypic behaviors in a dose-dependent manner, accompanied by increased neuronal apoptosis and upregulation of Hipk2-p53 pathway in the frontal cortex. Arsenic tumor protein p53 Homo sapiens
2 ASD children had significantly higher serum levels of 15 elements, among which arsenic, silicon, strontium, and vanadium were positively associated with both Hipk2 and p53. Arsenic tumor protein p53 Homo sapiens
3 Results from both the rat arsenic exposure and human case-control studies suggest a likely role of Hipk2-p53 pathway in ASD development induced by exposures to environmental pollutants such as arsenic. Arsenic tumor protein p53 Homo sapiens
4 Results from both the rat arsenic exposure and human case-control studies suggest a likely role of Hipk2-p53 pathway in ASD development induced by exposures to environmental pollutants such as arsenic. Arsenic tumor protein p53 Homo sapiens