Title : Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.

Pub. Date : 2021 Jun

PMID : 33244652






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS). Tyrosine tyrosyl-tRNA synthetase 1 Homo sapiens
2 RSV acts as a tyrosine antagonist and competes with it to bind to human tyrosyl-tRNA synthetase (TyrRS). Tyrosine tyrosyl-tRNA synthetase 1 Homo sapiens
3 However, retention of trans-RSV in the active site of TyrRS mimics its tyrosine-bound conformation that inhibits the auto-poly-ADP-ribos(PAR)ylation of PARP1. Tyrosine tyrosyl-tRNA synthetase 1 Homo sapiens