Title : Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients.

Pub. Date : 2021 May-Jun

PMID : 33243958






1 Functional Relationships(s)
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1 In vitro SRD5A2-negative BPH-1 cells were resistant to finasteride treatment, and SRD5A2 was re-expressed in BPH-1 cells when SRD5A2 was demethylated by 5-Aza-2"-deoxycytidine (5-Aza-CdR) or N-phthalyl-L-tryptophan (RG108). Decitabine 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Cricetulus griseus